Modern Prodrug Design for Targeted Oral Drug Delivery

Modern prodrug design for targeted oral drug delivery.

The molecular information that became available over the past two decades significantly influenced the field of drug design and delivery at large, and the prodrug approach in particular. While the traditional prodrug approach was aimed at altering various physiochemical parameters, e.g., lipophilicity and charge state, the modern approach to prodrug design considers molecular/cellular factors, ...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery

Prodrug Design vs. Drug Design

A drug is defined as a substance which is used in the cure, relief, diagnosis, treatment, or prevention of disease. The development of any potential drug commences with the study of the biochemistry and physiology behind a disease for which pharmaceutical intervention is feasible [1]. Prodrug is a term that was first introduced by Albert to signify a pharmacologically inactive chemical moiety t...

Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy

Aim We designed acid-labile methotrexate (MTX) targeting prodrug self-assembling nanoparticles loaded with curcumin (CUR) drug for simultaneous delivery of multi-chemotherapeutic drugs and combination cancer therapy. Methods A dual-acting MTX, acting as both an anticancer drug and as a tumor-targeting ligand, was coupled to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[aldehyde(polyethyl...